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Abstract #1853

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk1,2,3, Anna Lind1, Esben Thade Petersen1,4, Hartwig Roman Siebner1,5,6, and Anouk Marsman1
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, 2Department of Radiation Sciences, Umeå University, Umeå, Sweden, 3Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 4Center for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark, 5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 6Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

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