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Abstract #1852

Hippocampal concentration of glutamate: A comparative study of CEST and 1HMRS measurements at 7T.

Tomohisa Okada1, Ravi Prakash Reddy Nanga2, Koji Fujimoto1, Dinh Ha Duy Thuy1, Ravinder Reddy2, Hideto Kuribayashi3, Yuta Urushibata3, Ravi Teja Seethamraju4, Sinyeob Ahn5, and Tadashi Isa1
1Kyoto University, Kyoto, Japan, 2University of Pennsylvania, Philadelphia, PA, United States, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthineers USA, Burlington, MA, United States, 5Siemens Healthineers USA, Berkeley, CA, United States

Chemical exchange saturation transfer of the glutamate (GluCEST) contrast is considered from glutamate to be about 70 - 75 %. Its values at the bilateral hippocampus were compared to those of 1HMRS in 10 healthy subjects. Correlation between GluCEST contrast and glutamate from 1HMRS measurements of all subjects was marginally significant (r = 0.44, p = 0.054), but it was statistically significant (r = 0.56, p = 0.030) when analysis was limited to 1HMRS measurements with SNR ≥ 10. The GluCEST map gives regional difference in glutamate concentration in high resolution and is expected to facilitate investigation of the hippocampus.

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