Abstract #1852

Hippocampal concentration of glutamate: A comparative study of CEST and 1HMRS measurements at 7T.

Tomohisa Okada¹, Ravi Prakash Reddy Nanga², Koji Fujimoto¹, Dinh Ha Duy Thuy¹, Ravinder Reddy², Hideto Kuribayashi³, Yuta Urushibata³, Ravi Teja Seethamraju⁴, Sinyeob Ahn⁵, and Tadashi Isa¹

¹Kyoto University, Kyoto, Japan, ²University of Pennsylvania, Philadelphia, PA, United States, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Siemens Healthineers USA, Burlington, MA, United States, ⁵Siemens Healthineers USA, Berkeley, CA, United States

Chemical exchange saturation transfer of the glutamate (GluCEST) contrast is considered from glutamate to be about 70 - 75 %. Its values at the bilateral hippocampus were compared to those of ¹HMRS in 10 healthy subjects. Correlation between GluCEST contrast and glutamate from ¹HMRS measurements of all subjects was marginally significant (r = 0.44, p = 0.054), but it was statistically significant (r = 0.56, p = 0.030) when analysis was limited to ¹HMRS measurements with SNR ≥ 10. The GluCEST map gives regional difference in glutamate concentration in high resolution and is expected to facilitate investigation of the hippocampus.

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