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Abstract #1851

Human cerebral blood flow-metabolic uncoupling during acute hypoxia: A 1H Magnetic Resonance Spectroscopy & Arterial Spin Labelling study

Matthew Rogan1,2, Alexander Friend2, Gabriella Rossetti2, Jamie Macdonald2, Sam Oliver2, and Paul Mullins1
1The Bangor Imaging Centre, School of Psychology, Bangor University, Bangor, United Kingdom, 2Extremes Research Group, School of Sport Health and Exercise Science, Bangor University, Bangor, United Kingdom

Acute exposure to a moderate hypoxic environment leads to regional specific reduction in cerebral blood flow (rCBF) to the posterior cingulate cortex. Despite this, there is no concomitant reduction in the main excitatory neurotransmitter glutamate, as would be expected if the reductions in rCBF were coupled to neural activity. Our findings obtained using a combined 1H Magnetic Resonance Spectroscopy and Arterial Spin Labelling paradigm indicate that hypoxia disrupts neurovascular coupling, as it is presently understood, in a regionally specific manner.

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