Acute exposure to a moderate hypoxic environment leads to regional specific reduction in cerebral blood flow (rCBF) to the posterior cingulate cortex. Despite this, there is no concomitant reduction in the main excitatory neurotransmitter glutamate, as would be expected if the reductions in rCBF were coupled to neural activity. Our findings obtained using a combined 1H Magnetic Resonance Spectroscopy and Arterial Spin Labelling paradigm indicate that hypoxia disrupts neurovascular coupling, as it is presently understood, in a regionally specific manner.
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