Abstract #1858

Microstructural Attributes of Hemispheric Lateralization: A Combined Evaluation of Diffusion Spectrum Imaging and MR Spectroscopic Imaging

Xinnan Li¹, Kagari Abiko², Yuta Urushibata³, Hiroyuki Hamaguchi¹, Sinyeob Ahn⁴, and Khin Khin Tha^5,6

¹Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ²Hokkaido University Hospital, Sapporo, Japan, ³Siemens Healthineers, Tokyo, Japan, ⁴Siemens Healthineers, San Francisco, CA, United States, ⁵Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ⁶Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan

We evaluated the extent of laterality of the diffusion spectrum imaging (DSI) indices, and tested the association of their laterality to laterality of neurometabolite concentrations derived from whole-brain MR spectroscopic imaging (MRSI). Leftward asymmetry was observed mainly in the motor structures and rightward asymmetry in the structures associated with attention and emotion. A similar pattern of GFA, NQA and FA laterality in NAA/Cr and Cho/Cr and a reversed pattern in ADC were observed. The combination of DSI and MRSI can be helpful for a better understanding of ongoing neural processes. Hemispheric lateralization needs to be paid attention when interpreting pathologies.

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