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Abstract #1858

Microstructural Attributes of Hemispheric Lateralization:  A Combined Evaluation of Diffusion Spectrum Imaging and MR Spectroscopic Imaging

Xinnan Li1, Kagari Abiko2, Yuta Urushibata3, Hiroyuki Hamaguchi1, Sinyeob Ahn4, and Khin Khin Tha5,6
1Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 2Hokkaido University Hospital, Sapporo, Japan, 3Siemens Healthineers, Tokyo, Japan, 4Siemens Healthineers, San Francisco, CA, United States, 5Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 6Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan

We evaluated the extent of laterality of the diffusion spectrum imaging (DSI) indices, and tested the association of their laterality to laterality of neurometabolite concentrations derived from whole-brain MR spectroscopic imaging (MRSI). Leftward asymmetry was observed mainly in the motor structures and rightward asymmetry in the structures associated with attention and emotion. A similar pattern of GFA, NQA and FA laterality in NAA/Cr and Cho/Cr and a reversed pattern in ADC were observed. The combination of DSI and MRSI can be helpful for a better understanding of ongoing neural processes. Hemispheric lateralization needs to be paid attention when interpreting pathologies.

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