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Abstract #1859

Rosette spectroscopic imaging of epilepsy at 3T

Jullie W Pan1, Arun Antony2, Victor W Yushmanov1, Claud W Schirda2, and Hoby P Hetherington1
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2UPMC, Pittsburgh, PA, United States

Our group has implemented the rosette trajectory at 3T with 3dimensional phase and Hadamard encoding to achieve multi- and whole-slice spectroscopic images covering a total longitudinal 60mm. These acquisitions are applied in n=25 surgical epilepsy patients (15 medial temporal lobe; 10 neocortical epilepsy), evaluating metabolic dysfunction in terms of overlap with surgical target and outcome. In 19/25 patients the MRSI identified gyral regions of overlap between the abnormal MRSI and surgical therapy. Based on a 4% cut segregation of fractional volume of MRSI abnormalities, the outcome ILAE score was significantly lower (better) in patients with <=4% abnormality compared to >4%.

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