Our group has implemented the rosette trajectory at 3T with 3dimensional phase and Hadamard encoding to achieve multi- and whole-slice spectroscopic images covering a total longitudinal 60mm. These acquisitions are applied in n=25 surgical epilepsy patients (15 medial temporal lobe; 10 neocortical epilepsy), evaluating metabolic dysfunction in terms of overlap with surgical target and outcome. In 19/25 patients the MRSI identified gyral regions of overlap between the abnormal MRSI and surgical therapy. Based on a 4% cut segregation of fractional volume of MRSI abnormalities, the outcome ILAE score was significantly lower (better) in patients with <=4% abnormality compared to >4%.
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