Cognitive deficits often persist beyond remission in major depressive disorder (MDD). CDP-choline has shown improvements in cognition in other populations characterized by cognitive deficits. These improvements may be due to interactions with the glutamatergic and cholinergic systems. The aim of this ongoing study was to assess the neurochemical response through magnetic resonance spectroscopy to the acute administration of CDP-choline compared with placebo in the anterior cingulate in a group of remitted MDD participants. Early results indicate possible relationships between glutamate and myo-inositol concentrations, and CDP-choline.