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Abstract #1860

CDP-choline may influence metabolite levels in the anterior cingulate of people in remission of depression

Reggie Taylor1, Emma Lynn1,2, Pierre Blier1,2, Gerd Melkus3,4, Verner Knott1,2, and Natalia Jaworska1,2
1Institute of Mental Health Research, Ottawa, ON, Canada, 2Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, 3The Ottawa Hospital, Ottawa, ON, Canada, 4Radiology, University of Ottawa, Ottawa, ON, Canada

Cognitive deficits often persist beyond remission in major depressive disorder (MDD). CDP-choline has shown improvements in cognition in other populations characterized by cognitive deficits. These improvements may be due to interactions with the glutamatergic and cholinergic systems. The aim of this ongoing study was to assess the neurochemical response through magnetic resonance spectroscopy to the acute administration of CDP-choline compared with placebo in the anterior cingulate in a group of remitted MDD participants. Early results indicate possible relationships between glutamate and myo-inositol concentrations, and CDP-choline.

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