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Abstract #1861

N-Acetyl Aspartate and Myo-Inositol as biomarkers of HIV infection in the brain

Teddy Salan1, Sameer Vyas2, Paramjeet Singh2, Sulaiman Sheriff3, Mahendra Kumar4, and Varan Govind1
1Radiology, University of Miami, Miami, FL, United States, 2Postgraduate Institute for Medical Education & Research, Chandigarh, India, 3University of Miami, Miami, FL, United States, 4Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, United States

The purpose of this study is to determine whether magnetic resonance spectroscopic imaging (MRSI) can identify metabolite biomarkers of HIV infection in the brain. Concentrations of N-acetyl aspartate (NAA), choline (CHO), creatine (CR), myo-inositol (MI), and glutamate and glutamine (GLX) were measured at the whole-brain level and compared between HIV+ and healthy control subjects. Significant reductions in NAA and increases in MI are observed throughout the brain, while the concentrations of other metabolites show no significant change.

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