Abstract #1862

Automatic detection of Multiple Sclerosis cortical lesions based on 3D-FLAIR and MP2RAGE sequences

Francesco La Rosa^1,2, Ahmed Abdulkadir³, Mário João Fartaria^1,2,4, Reza Rahmanzadeh^5,6, Riccardo Galbusera^5,6, Jean-Philippe Thiran^1,2, Cristina Granziera^5,6, and Meritxell Bach Cuadra^1,2

¹LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Radiology Department, Center for Biomedical Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³Universitäre Psychiatrische Dienste and University of Bern, Bern, Switzerland, ⁴Siemens Healthcare AG Switzerland, Lausanne, Switzerland, ⁵Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ⁶Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland

Multiple Sclerosis cortical lesions are not readily visible in conventional MRI, but they are clinically highly relevant and have been recently included in the MS diagnostic criteria. However, advanced MRI sequences such as the MP2RAGE are needed in order to identify them visually. In this work, we propose an automatic method based on a convolutional neural network to automatically detect cortical lesions. In a cohort of 84 patients with FLAIR and MP2RAGE acquisitions our framework achieves a 77% cortical lesion detection rate with a 26% lesion-wise false positive rate.

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