Abstract #1920

Human Mesenchymal Stem Cell Donor Effects on Apparent Diffusion Coefficient in a Rodent Stroke Model at 21.1 T

F. Andrew Bagdasarian^1,2, Shannon Helsper^1,2, Xuegang Yuan^1,2, Jens T. Rosenberg¹, and Samuel Colles Grant^1,2

¹National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ²Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study extends diffusion weighted imaging at 21.1-T to identify the pattern of potential recovery of apparent diffusion coefficient (ADC) in rodent ischemic stroke with novel stem cell therapy using dissociated aggregate human mesenchymal stem cells (d-hMSC) from different donors. All scanning was performed at 21.1 T with the goal of quantitatively assessing treatment efficacy longitudinally, spanning a 3 weeks post ischemia. Results show donor resultant ADC discrepancies at various time points and regions.

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