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Abstract #1921

Long-term Structural Brain Changes in Adult Rats After Focal Ischemic Stroke

Warda Syeda1,2,3, Charlotte Ermine1, David Wright4, Vanessa Brait1, Lachlan Thompson1, Jess Nithianantharajah1, Scott Kolbe4, Leigh Johnston1,2, and Amy Brodtmann1
1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2The Melbourne Brain Centre Imaging Unit, The University of Melbourne, Melborne, Australia, 3Melbourne Neuropsychiatry Centre, The University of Melbourne, Melborne, Australia, 4Department of Neuroscience, Monash University, Melbourne, Australia

Accumulating clinical evidence suggests remote neurodegeneration occurs in non-ischemic brain regions distant to the site of infarction in stroke, driven by both axonal degeneration and global brain inflammation. Prior preclinical studies of remote degeneration have mainly focused on brain changes over a few days or weeks post-stroke. We investigated long-term structural brain changes in an endothelin-1 model of mild focal ischemic stroke in rats, using a clinically relevant period of 48-weeks. Serial structural and diffusion-weighted MRI data were used to assess dynamic volume and white matter trajectories. We found significant cortical atrophy and white matter alterations, suggesting widespread stroke-related degenerations.

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