The study, performed on a rat model of ischemic stroke, aimed to evaluate a recently proposed myelin biomarker, macromolecular proton fraction (MPF) as a non-invasive tool for monitoring recovery after stroke. Longitudinal observations showed the different time courses of MPF evolution in the infarct zones undergoing subsequent demyelination (DZ) or remyelination (RZ). After a sharp decrease at days 1-5 after MCAO, MPF showed a further decline in the DZ and a restoration in the RZ to day 56. These findings were confirmed by histology which showed similar tissue evolution zones and enhancement of neurogenesis and oligodendrogenesis in the ischemic core.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords