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Abstract #1923

Macromolecular proton fraction as a marker of myelin recovery in ischemic stroke

Marina Khodanovich1, Ilya Gubskiy 2, Darya Namestnikova 2, Marina Kudabaeva1, Valentina Glazacheva1, Tatyana Anan'ina1, and Vasily Yarnykh1,3
1Tomsk State University, Tomsk, Russian Federation, 2Pirogov Russian National Research Medical University, Moscow, Russian Federation, 3University of Washington, Seattle, WA, United States

The study, performed on a rat model of ischemic stroke, aimed to evaluate a recently proposed myelin biomarker, macromolecular proton fraction (MPF) as a non-invasive tool for monitoring recovery after stroke. Longitudinal observations showed the different time courses of MPF evolution in the infarct zones undergoing subsequent demyelination (DZ) or remyelination (RZ). After a sharp decrease at days 1-5 after MCAO, MPF showed a further decline in the DZ and a restoration in the RZ to day 56. These findings were confirmed by histology which showed similar tissue evolution zones and enhancement of neurogenesis and oligodendrogenesis in the ischemic core.

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