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Abstract #1924

Remote ischemic conditioning in a rat model of acute ischemic stroke: a two-centre study with translational longitudinal MRI

Marlene Wiart1, Maryna Basalay2, Fabien Chauveau3, Chloe Dumot1, Christelle Leon1, Camille Amaz4, Radu Bolbos5, Diana Cash6, Eugene Kim6, Tae-Hee Cho7, Norbert Nighoghossian7, Sean Davidson2, Michel Ovize1, and Derek Yellon2
1Université Lyon, CarMeN laboratory, Inserm U1060, Lyon, France, 2The Hatter Cardiovascular Institute, London, United Kingdom, 3Université Lyon, Lyon Neuroscience Research Center, CNRS UMR5292, Inserm U1028, Lyon, France, 4Clinical Investigation Center, HCL, Lyon, France, 5CERMEP-Imagerie du Vivant, Bron, France, 6Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, 7Stroke Medicine, Université Lyon, CREATIS CNRS UMR 5220-INSERM U1206, Lyon, France

The main objective of this study was to test the neuroprotective effects of remote ischemic conditioning (RIC: 4 cycles of 5-min hind limb ischemia interleaved with 5-min reperfusion) in a rat model of transient ischemic stroke (90 minutes) in a two-center study using translational MR imaging endpoints. Neuroscores and edema-corrected infarct size measured at 24h on T2-weighted MRI and expressed as percentage of the area at risk on per-occlusion MRI were significantly reduced in the RIC-treated group compared to the control group. The use of longitudinal MRI increases results robustness, which is greatly needed for successful RIC clinical translation.

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