Abstract #1924

Remote ischemic conditioning in a rat model of acute ischemic stroke: a two-centre study with translational longitudinal MRI

Marlene Wiart¹, Maryna Basalay², Fabien Chauveau³, Chloe Dumot¹, Christelle Leon¹, Camille Amaz⁴, Radu Bolbos⁵, Diana Cash⁶, Eugene Kim⁶, Tae-Hee Cho⁷, Norbert Nighoghossian⁷, Sean Davidson², Michel Ovize¹, and Derek Yellon²

¹Université Lyon, CarMeN laboratory, Inserm U1060, Lyon, France, ²The Hatter Cardiovascular Institute, London, United Kingdom, ³Université Lyon, Lyon Neuroscience Research Center, CNRS UMR5292, Inserm U1028, Lyon, France, ⁴Clinical Investigation Center, HCL, Lyon, France, ⁵CERMEP-Imagerie du Vivant, Bron, France, ⁶Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, ⁷Stroke Medicine, Université Lyon, CREATIS CNRS UMR 5220-INSERM U1206, Lyon, France

The main objective of this study was to test the neuroprotective effects of remote ischemic conditioning (RIC: 4 cycles of 5-min hind limb ischemia interleaved with 5-min reperfusion) in a rat model of transient ischemic stroke (90 minutes) in a two-center study using translational MR imaging endpoints. Neuroscores and edema-corrected infarct size measured at 24h on T2-weighted MRI and expressed as percentage of the area at risk on per-occlusion MRI were significantly reduced in the RIC-treated group compared to the control group. The use of longitudinal MRI increases results robustness, which is greatly needed for successful RIC clinical translation.

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