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Abstract #1925

Changes in Quantitative Magnetization Transfer MR in the Mouse Brain After Transient Cerebral Ischemia

Grzegorz Kwiatkowski1, Georgios Louloudis1, Jan Klohs1, and Sebastian Kozerke2
1Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 2ETH Zurich, Zurich, Switzerland

Quantitative analysis of magnetization transfer (qMT) based on a two-pool model was employed to characterized changes in the mouse brain following a transient middle cerebral artery occlusion (tMCAO) model of cerebral ischemia.The changes in qMT were compared to the standard MR metrics of an ischemic lesion (T1, T2, ADC, FLAIR) to examine the possible overlap of mechanisms affecting these magnetic resonance imaging contrasts. Notable changes of all MR metrics were found in the brain of the tMCAO group while only the qMT analysis revealed significant alterations in the sham-operated animals.

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