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Abstract #1926

Functional Reorganization and Behavioral Recovery in Rats with Repetitive Closed-head Injury after Drug Treatment

Yu-Chieh Jill Kao1,2,3, Chia-Feng Lu4, Bao-Yu Hsieh5, and Cheng-Yu Chen1,2,3,6
1Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, 4Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 5Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 6Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

Significant improvement of locomotor activity and anxiety-like behavior along with reorganization of motor and default mode network was observed after NAC or NAC plus MINO treatment after repetitive closed-head injury, suggesting tentative treatment using drugs in patients with repetitive mild traumatic brain injury.

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