Abstract #1926

Functional Reorganization and Behavioral Recovery in Rats with Repetitive Closed-head Injury after Drug Treatment

Yu-Chieh Jill Kao^1,2,3, Chia-Feng Lu⁴, Bao-Yu Hsieh⁵, and Cheng-Yu Chen^1,2,3,6

¹Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ⁴Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁵Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ⁶Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

Significant improvement of locomotor activity and anxiety-like behavior along with reorganization of motor and default mode network was observed after NAC or NAC plus MINO treatment after repetitive closed-head injury, suggesting tentative treatment using drugs in patients with repetitive mild traumatic brain injury.

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