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Abstract #1927

Highly specific and direct assessment of microscopic anisotropy following traumatic brain injury using diffusion correlation imaging (DCI)

Dan Benjamini1,2, Michal Komlosh1,2, Elizabeth Hutchinson3, and Peter Basser1
1National Institutes of Health, Bethesda, MD, United States, 2Uniformed Service University of the Health Sciences, Bethesda, MD, United States, 3The University of Arizona, Tucson, AZ, United States

Diffusion MRI techniques that extend beyond diffusion tensor imaging (DTI) – including double diffusion encoding (DDE) – could provide more specific tools to probe abnormalities in disease or injury states. Here, DDE is applied to reveal the diffusion correlation spectrum on a voxelwise basis, which allows to directly assess the microscopic anisotropy in healthy and injured ferret spinal cords.

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