Abstract #1927

Highly specific and direct assessment of microscopic anisotropy following traumatic brain injury using diffusion correlation imaging (DCI)

Dan Benjamini^1,2, Michal Komlosh^1,2, Elizabeth Hutchinson³, and Peter Basser¹

¹National Institutes of Health, Bethesda, MD, United States, ²Uniformed Service University of the Health Sciences, Bethesda, MD, United States, ³The University of Arizona, Tucson, AZ, United States

Diffusion MRI techniques that extend beyond diffusion tensor imaging (DTI) – including double diffusion encoding (DDE) – could provide more specific tools to probe abnormalities in disease or injury states. Here, DDE is applied to reveal the diffusion correlation spectrum on a voxelwise basis, which allows to directly assess the microscopic anisotropy in healthy and injured ferret spinal cords.

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