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Abstract #1930

Longitudinal Study of Resting State Connectivity in a Rat Model of Alcohol Use Disorder at Ultrahigh Fields

Hannes M. Wiesner1, Wei Zhu1, Yi Zhang1, Manuel Esguerra2, Colleen Hutchison2, Mark J. Thomas2, Xiao-Hong Zhu1, and Wei Chen1
1Department of Radiology, CMRR, University of Minnesota Medical School, Minneapolis, MN, United States, 2Departments of Neuroscience and Psychology, University of Minnesota, Minneapolis, MN, United States

Resting state fMRI (rs-fMRI) has been used to investigate alcohol use disorder (AUD), mostly in humans; and a wide array of commonly induced neurological changes due to acute and chronic use have been reported. In this work, we established a rat model of AUD to longitudinally study the effects of chronic alcohol abuse on the functional brain connectivity using rs-fMRI at ultrahigh fields. Preliminary results revealed potential changes in reward-processing circuit connectivity and global brain activity. Further research is advised to quantify early effects observed in and between different neural structures (NAc/IBST/PreL/IL and ACC) during withdrawal stress and relapse.

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