Abstract #1930

Longitudinal Study of Resting State Connectivity in a Rat Model of Alcohol Use Disorder at Ultrahigh Fields

Hannes M. Wiesner¹, Wei Zhu¹, Yi Zhang¹, Manuel Esguerra², Colleen Hutchison², Mark J. Thomas², Xiao-Hong Zhu¹, and Wei Chen¹

¹Department of Radiology, CMRR, University of Minnesota Medical School, Minneapolis, MN, United States, ²Departments of Neuroscience and Psychology, University of Minnesota, Minneapolis, MN, United States

Resting state fMRI (rs-fMRI) has been used to investigate alcohol use disorder (AUD), mostly in humans; and a wide array of commonly induced neurological changes due to acute and chronic use have been reported. In this work, we established a rat model of AUD to longitudinally study the effects of chronic alcohol abuse on the functional brain connectivity using rs-fMRI at ultrahigh fields. Preliminary results revealed potential changes in reward-processing circuit connectivity and global brain activity. Further research is advised to quantify early effects observed in and between different neural structures (NAc/IBST/PreL/IL and ACC) during withdrawal stress and relapse.

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