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Abstract #1931

Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia

Yu Song1,2, Hongbin Han2,3,4, Qingwei Song1, Yajuan Gao2,3,4, Rui Wang2,3,4, Xianjie Cai2,3,4, Yumeng Cheng2,3,4, and Zeqing Tang2,3,4
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, China, 3Department of Radiology, Peking University Third Hospital, Beijing, China, 4Institute of Medical Technology(IMT)of Peking University Health Science Center(PKUHSC), Beijing, China

Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a sin- gle intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.

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