Abstract #1934

Association of white matter deficits with cerebral blood flow in cerebral hypoperfusion mouse model as revealed by in-vivo multi-modal MRI

Fangrong Zong¹, Yan Zhuo^2,3, Chengya Dong⁴, Baoshan Qiu⁴, Shunyin Zhao⁴, Baogui Zhang⁵, Yilong Wang⁴, and Xiangrong Liu⁴

¹Centre for Advanced Magnetic Resonance Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ³The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, ⁴China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China, ⁵Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China

The underlying mechanism of vascular dementia remains unclear which leads to difficulties in developing specific disease treatments. This contribution firstly developed a multi-modal MRI approach on a mouse model with unilateral carotid artery stenosis as non-invasive measures. A positive correlation was built between fractional anisotropy and cerebral blood flow under hypoperfusion conditions, which provides insights into understanding the pathological mechanism of vascular dementia.

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