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Abstract #1935

Functioning of the glucose transporter and glymphatic systems in the tauopathy AD mouse brain studied by onVDMP MRI and D-glucose infusion

Lin Chen1,2, Zhiliang Wei1,2, Kannie W.Y. Chan1,2,3, Jianpan Huang4, Xiang Xu1,2, Philip C. Wong5,6, Hanzhang Lu1,2, Peter C.M. van Zijl1,2, Tong Li5,6, and Jiadi Xu1,2
1Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 4City University of Hong Kong, Hong Kong, China, 5Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States

In this study, we used onVDMP MRI to detect glucose uptake in tauopathy Alzheimer's disease (AD) mouse brain. Compared to wild-type mice, significantly reduced glucose uptake was observed in both cerebrospinal fluid (CSF) and parenchyma of AD mouse brain. Clearance of glucose through CSF was found in wild-type mice, but not in AD mice, which implicates dysfunction of the glymphatic system in AD mouse brain. The results in this study suggest that onVDMP MRI could be a cost-effective and widely available method for evaluating the functions of glucose transporter and glymphatic system, and hence diagnosing AD.

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