Abstract #1936

Longitudinal brain connectome reorganization in a tauopathy mouse model of Alzheimer's disease

Laetitia Degiorgis¹, Marion Sourty^1,2, Julien Lamy¹, Vincent Noblet¹, Meltem Karatas^1,3,4, Thomas Bienert⁴, Marco Reisert⁴, Anne-Laurence Boutillier⁵, Jean-Paul Armspach¹, Frédéric Blanc^1,6, and Laura Harsan^1,7

¹University of Strasbourg and CNRS, ICube Laboratory UMR 7357, Strasbourg, France, ²The University of Sydney, Faculty of Engineering, School of Aerospace, Mechanical and Mechatronic Engineering, Sydney, Australia, ³CNRS, University of Strasbourg, INCI, UMR 7168, Strasbourg, France, ⁴Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ⁵Laboratoire de Neuroscience Cognitives et Adaptatives, Strasbourg, France, ⁶University Hospital of Strasbourg, CM2R (Memory Resource and Research Centre), Day Hospital, Geriatrics Department, Strasbourg, France, ⁷Department of Biophysics and Nuclear Medicine, University Hospital of Strasbourg, Strasbourg, France

MRI is a unique tool to understand the complexity of the brain functional and structural communication evolution over time. Among the main mechanisms of AD, tauopathy remains poorly studied in preclinical imaging. We used graph theory approaches and DTI analysis in a longitudinal study of Thy-Tau22 mice, associated with behavioral evaluation. Alterations of the cholinergic septal circuitry, supporting memory and emotional processes, were found as the main hallmark of the progression of the pathology, associated with default mode network dysfunction, both starting before the first memory deficits.

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