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Abstract #1937

Optogenetic modulation and rsfMRI mapping of depression related functional brain networks in the mouse

Laura-Adela Harsan1, Laetitia Degiorgis1, Julien Todeschi2, Lea Becker3, Maxence Thomas de la Pintière1, Victor Mathis3, Chrystelle Po1, and Ipek Yalcin3
1ICube: Engineering science, computer science and imaging laboratory, University of Strasbourg, Strasbourg, France, 2ICube: Engineering science, computer science and imaging laboratory, Neurosurgery Department, University Hospital Strasbourg, University of Strasbourg, Strasbourg, France, 3Institute de Neurosciences Cellulaires et Intégratives, University of Strasbourg-CNRS, Strasbourg, France

The main objective of this study is to modulate and map the anterior cyngulate cortex (ACC) functional connectivity (FC) pathways underlying depression development in a mouse model. We use the optogenetic approaches to create the depression phenotype in mice, by activating the pyramidal ACC neurons expressing Channel rhodopsin 2 (ChR). We further use resting state functional MRI (rsfMRI) as non-invasive read-out of the effects at the level of functional brain connectivity. Four consecutive sessions of optogenetic ACC stimulation induced strong depression phenotype and major modifications of the functional mouse brain connectivity including perturbed mesocorticolimbic pathways and default mode network patterns

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