Meeting Banner
Abstract #1938

Temporal alterations of GluCEST contrast in a rat model of cuprizone-induced demyelination and remyelination

Do-Wan Lee1, Chul-Woong Woo2, Hwon Heo3, Jae-Im Kwon2, Yeon Ji Chae3, Su Jung Ham4, Jeong Kon Kim1, Kyung Won Kim1,4, Dong-Cheol Woo2,3, and Dong-Hoon Lee5
1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 2Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, 3Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 4Asan Image Research, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, 5Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia

Research on changes to glutamate signaling in the white matter of demyelinating diseases may provide important biophysical information for diagnostic and prognostic assessment. We attempted to evaluate glutamate signals in a cuprizone-induced rat model of demyelination by GluCEST imaging. GluCEST imaging provides in vivo image contrast of changing glutamate concentrations during demyelination and subsequent remyelination. We also performed histological validation to analyze the state of myelinated axons. GluCEST imaging could be a useful tool to evaluate brain metabolism in demyelination and remyelination models and provide quantitative results that are highly representative of changes to glutamate levels in vivo.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here