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Abstract #1939

MR elastography and DTI for monitoring microstructural changes in the developing brain of Poly (I:C)-induced maternal immune activated rats.

Lucy Liu1,2, Andre Bongers2, Lynne Bilston1,2, and Lauriane Jugé1,2
1Neuroscience Research Australia, Sydney, Australia, 2University of New South Wales, Sydney, Australia

Maternal infection during pregnancy can cause enlarged ventricles and compromise brain microstructure, which conventional imaging techniques cannot identify. We investigated the potential of magnetic resonance elastography (MRE) and diffusion tensor imaging (DTI) in detecting brain microstructural changes in offspring of Poly (I:C)-induced maternal immune activated rats. Results showed that DTI and MRE were sensitive to neurodevelopmental microstructural changes, but not to subtle longitudinal microstructural changes related to maternal infection. DTI showed that white matter injury differs between perinatal and adolescent Poly(I:C) rats, while MRE was not sensitive enough to detect subtle compromise of gray matter microstructure in Poly (I:C) rats.

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