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Abstract #1941

MRI assessment of vascular disruption in tau pathology animal model (rTg4510 mouse) of Alzheimer disease

Kwangyeol Baek1, Rachel Bennett2, Bradley Hyman2, Woo Hyun Shim3, and Young Ro Kim4,5
1School of Biomedical Convergence Engineering, Pusan National University, Busan, Republic of Korea, 2Department of Neurology, Massachusetts General Hospital and Harvard Medical School,, Boston, MA, United States, 3Department of Radiology, Asan Medical Center, Seoul, Korea, Republic of, 4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States

We assessed vascular disruption in rTg4510 mouse (age of 6 and 9 months), a tau expressing transgenic animal model of Alzheimer’s disease, using MRI metrics such as vessel size index (VSI), Gd-DTPA leakge through BBB and water exchange index (WEI). The rTg4510 mice showed age-dependent expansion of the hippocampal lesion and profound vascular alteration around the hippocampal lesion: Increase in VSI, mild Gd-DTPA leakage and increased WEI. Our findings suggest the role of vascular components in development of Alzheimer’s disease with tau pathology. Vascular MRI assessments might have a potential application in early diagnosis and monitoring of Alzheimer’s disease.

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