Abstract #1942

Neurite orientation dispersion and density imaging of rat brain microstructural changes due to middle cerebral artery occlusion at a 3T MRI

Zhenxiong Wang^1,2, Wenzhen Zhu¹, Shun Zhang¹, Guiling Zhang¹, Mehran Shaghaghi², and Kejia Cai²

¹Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Departments of Radiology, Department of Bioengineering, and the Center for MR Research, Chicago, IL, United States

In this study we demonstrated the feasibility of longitudinal neurite orientation dispersion and density imaging (NODDI) in characterizing the microstructural alterations in rat brain tissues due to middle cerebral artery occlusion at a 3T MRI and validated the NODDI parameters with histology.

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