Abstract #1943

Cerebral metabolic rate at three hours post injury predicts 24-hour neurological outcome in a rat model of cardiac arrest

Zhiliang Wei^1,2, Qihong Wang³, Sung-Min Cho⁴, Romergryko Geocadin⁴, Hiren R. Modi³, Nitish V. Thakor³, and Hanzhang Lu^1,2,3

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cardiac arrest (CA) is associated with low survival rate and unfavorable outcomes despite maximal medical care. For determining the timing of acute brain injury and delivering aggressive intervention at early stage to improve neurologic outcomes, an early-stage biomarker is compulsory. Here, we utilized MRI techniques to reveal the temporal trajectories of brain’s blood supply, oxygenation, and energy consumption in the first few hours following return-of-spontaneous-circulation, and found early physiologic measure is associated with 24-h neurologic deficit score. This finding may potentially facilitate the future research on CA management by providing a sensitive physiologic biomarker to determine appropriate medical intervention.

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