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Abstract #1945

Cellular correlates of gray matter volume changes identified with two-photon microscopy and magnetic resonance morphometry in the mouse brain  

Claudia Falfán-Melgoza1, Livia Asan2, Johannes Knabbe2, Carlo Beretta2,3, Thomas Kuner2, and Wolfgang Weber-Fahr1
1RG Translational Imaging, Central Institute of Mental Heath, Mannheim, Germany, 2Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany, 3CellNetworks Math-Clinic, Bioquant BQ001, Heidelberg University, Heidelberg, Germany

Insights gained from Voxel Based morphometry (VBM) tremendously advance the understanding of neurologic and psychiatric diseases. However, the cellular basis of VBM changes remains largely unclear. We used longitudinal two-photon fluorescence and magnetic resonance imaging in mice to explore the cellular basis of VBM. Our data shows that MRI volume changes are only limited reflected by physical volume changes, yet dominated by cellular composition and cytoarchitectural characteristics. This has great implications for findings in neuroimaging in general, and the novel approach introduced by this study can be applied to various disease models to potentially unravel key mechanisms of brain pathophysiology.

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