Abstract #1946

In-vivo measurements of physiological optics of mouse crystallin lens using MRI

Xingzheng Pan¹, Eric R. Muir², Paul J. Donaldson^1,3, Ehsan Vaghefi¹, Zhao Jiang², Caterina Sellitto⁴, and Thomas W. White⁴

¹School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand, ²Department of Radiology, School of Medicine, Stony Brook University, Stony Brook, NY, United States, ³Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand, ⁴Department of Physiology & Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY, United States

The physiological optics of the crystallin lens depend on its water content, water-bound protein ratios and surface geometry^1,2. To maintain these properties, the lens generate a circulating flux of ions that actively removes water from the lens center via an intracellular pathway mediated by gap junction channels³. In this study, we established and optimised T1&T2 mapping and structural scan to study the physiological optics the mouse lens at 7T. These protocols were then applied to a transgenic mouse model in which we have genetically modified the number of gap junction channels to alter the removal of water from the lens.

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