Abstract #1946

In-vivo measurements of physiological optics of mouse crystallin lens using MRI

Xingzheng Pan¹, Eric R. Muir², Paul J. Donaldson^1,3, Ehsan Vaghefi¹, Zhao Jiang², Caterina Sellitto⁴, and Thomas W. White⁴

¹School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand, ²Department of Radiology, School of Medicine, Stony Brook University, Stony Brook, NY, United States, ³Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand, ⁴Department of Physiology & Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY, United States

The physiological optics of the crystallin lens depend on its water content, water-bound protein ratios and surface geometry^1,2. To maintain these properties, the lens generate a circulating flux of ions that actively removes water from the lens center via an intracellular pathway mediated by gap junction channels³. In this study, we established and optimised T1&T2 mapping and structural scan to study the physiological optics the mouse lens at 7T. These protocols were then applied to a transgenic mouse model in which we have genetically modified the number of gap junction channels to alter the removal of water from the lens.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.