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Abstract #1946

In-vivo measurements of physiological optics of mouse crystallin lens using MRI

Xingzheng Pan1, Eric R. Muir2, Paul J. Donaldson1,3, Ehsan Vaghefi1, Zhao Jiang2, Caterina Sellitto4, and Thomas W. White4
1School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand, 2Department of Radiology, School of Medicine, Stony Brook University, Stony Brook, NY, United States, 3Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand, 4Department of Physiology & Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY, United States

The physiological optics of the crystallin lens depend on its water content, water-bound protein ratios and surface geometry1,2. To maintain these properties, the lens generate a circulating flux of ions that actively removes water from the lens center via an intracellular pathway mediated by gap junction channels3. In this study, we established and optimised T1&T2 mapping and structural scan to study the physiological optics the mouse lens at 7T. These protocols were then applied to a transgenic mouse model in which we have genetically modified the number of gap junction channels to alter the removal of water from the lens.

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