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Abstract #1947

Implementation and optimization of steady state free precession MRI for mapping BBB leakage in mouse brain at 9.4T

Frederick C. Damen1, Steve Zaldua2, Jin Gao3, Weiguo Li3, Leon Tai2, and Kejia Cai1
1Radiology, University of Illinois at Chicago, CHICAGO, IL, United States, 2Anatomy and Cell Biology, University of Illinois at Chicago, CHICAGO, IL, United States, 3Research Resources Center, University of Illinois at Chicago, CHICAGO, IL, United States

In neurodegenerative diseases, e.g., Alzheimer’s disease, it is important to study cerebral blood flow (CBF) and blood brain barrier (BBB) permeability. Arterial Spin Labeling (ASL), used to measure CBF, is hampered by physiological variability, requiring many averages, and thus, fast imaging. Echo Planner Imaging, the most used fast imaging method, suffers from massive distortions and blurring for mice brain imaging at high field MRI. Alternatively, in this study we successfully implemented steady state free precession fast imaging for the measurement of the BBB leakage in mouse brain at 9.4T.

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