Abstract #1947

Implementation and optimization of steady state free precession MRI for mapping BBB leakage in mouse brain at 9.4T

Frederick C. Damen¹, Steve Zaldua², Jin Gao³, Weiguo Li³, Leon Tai², and Kejia Cai¹

¹Radiology, University of Illinois at Chicago, CHICAGO, IL, United States, ²Anatomy and Cell Biology, University of Illinois at Chicago, CHICAGO, IL, United States, ³Research Resources Center, University of Illinois at Chicago, CHICAGO, IL, United States

In neurodegenerative diseases, e.g., Alzheimer’s disease, it is important to study cerebral blood flow (CBF) and blood brain barrier (BBB) permeability. Arterial Spin Labeling (ASL), used to measure CBF, is hampered by physiological variability, requiring many averages, and thus, fast imaging. Echo Planner Imaging, the most used fast imaging method, suffers from massive distortions and blurring for mice brain imaging at high field MRI. Alternatively, in this study we successfully implemented steady state free precession fast imaging for the measurement of the BBB leakage in mouse brain at 9.4T.

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