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Abstract #1948

Quantitative in vivo 19F MRI of mouse brain inflammation using a cryogenic RF surface probe and RARE

Paula Ramos Delgado1, Christian Prinz1, Jason M. Millward1, Helmar Waiczies2, Ludger Starke1, Joao Periquito1, Laura Boehmert1, Thoralf Niendorf1,3, Andreas Pohlmann1, and Sonia Waiczies1
1Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2MRI.tools GmbH, Berlin, Germany, 3Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

The low SNR inherent to fluorine (19F) MRI necessitates sensitivity-enhancing methods. SNR-efficient imaging techniques such as RARE and SNR-enhancing cryogenically-cooled RF coils (CRP) create new challenges. The strong spatially-varying B1 fields of transceive surface RF coils hamper quantification and no analytical signal intensity equation for B1+ correction exists for RARE. We developed a B1 correction method that makes use of experimental data to model the signal intensity from RARE and we established a workflow to correct and quantify 19F MR signals originating from inflammatory regions of the mouse brain that were acquired using a 19F-CRP.

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