Abstract #1949

Effects of anesthetic conditions on the mouse cerebral oxygen saturation measured by QSM

Jérémie P. Fouquet¹, Luc Tremblay¹, Andreas Deistung², Renat Sibgatulin³, Martin Krämer³, Karl-Heinz Herrmann³, Réjean Lebel¹, Jürgen R. Reichenbach³, and Martin Lepage¹

¹Sherbrooke Molecular Imaging Center (CIMS), Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Faculty of Medicine, Universitätsklinikum Halle, Halle, Germany, ³Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

Anesthetic conditions may have important effects on the blood oxygen saturation in rodents. However, the size of those effects has not been directly quantified in the mouse brain. We use Quantitative Susceptibility Mapping to provide a direct estimate of the oxygen saturation in the mouse brain under anesthesia. Three commonly used anesthetics, namely isoflurane, dexmedetomidine, and ketamine-xylazine, are evaluated. The effect of breathing gas is also evaluated.

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