Resting state fMRI study in animal model often involved use of anesthetics, but the effect of anesthetics on the spontaneous neural activity is not well known. We investigated how different types and doses of anesthetics (isoflurane and α-chloralose) influence the LFP activity and functional connectivity in comparison with the awake state. We observed distinct effects of these anesthetics on spontaneous neural activity (e.g. burst-suppression pattern and nonspecific correlation for high dose of isoflurane) and evoked response (e.g. potentified sensory-evoked response in bilateral cortices with α-chloralose). The effect of anesthetics should be taken into account in animal resting state fMRI studies.
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