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Abstract #1951

A Whole-Brain Map and Assay Parameter Analysisof Mouse VTA Dopaminergic Activation

Horea-Ioan Ioanas1, Bechara John Saab2, and Markus Rudin1
1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2Preclinical Laboratory for Translational Research into Affective Disorder, University of Zurich Psychiatric Hospital, Zurich, Switzerland

The definition of neurophenotypes for the function of key neurotransmitter systems is vital to the improvement of drug development in psychopharmacology. In this study we present a whole-brain map of stimulus-evoked VTA dopaminergic function in mice, alongside a parameter analysis for this novel assay. This study shows overall coherence between functional and known structural connectivity, but provides additional evidence for functional connectivity towards the dorsal striatum (first indicated in the rat model). We propose that this thoroughly explored new assay can provide an invaluable read-out for dopaminergic dysfunction and dopaminergic intervention modelling.

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