The definition of neurophenotypes for the function of key neurotransmitter systems is vital to the improvement of drug development in psychopharmacology. In this study we present a whole-brain map of stimulus-evoked VTA dopaminergic function in mice, alongside a parameter analysis for this novel assay. This study shows overall coherence between functional and known structural connectivity, but provides additional evidence for functional connectivity towards the dorsal striatum (first indicated in the rat model). We propose that this thoroughly explored new assay can provide an invaluable read-out for dopaminergic dysfunction and dopaminergic intervention modelling.
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