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Abstract #1952

Aryl hydrocarbon receptor antagonism before reperfusion attenuates cerebral ischemia/reperfusion injury in rats

Jae-Im Kwon1, Hwon Heo2, Sang Tae Kim1, Su Jeong Ham1, Yeon Ji Chae1, Young Jin Kim1, Do-Wan Lee2, Kyung Won Kim3, Dong Cheol Woo1,2, and Chul-Woong Woo1
1Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, 2Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 3Radiology, Asan Medical Center, Seoul, Korea, Republic of

Emerging evidence suggests that aryl hydrocarbon receptor (AhR) antagonism could attenuate neuronal damage caused by transient ischemic stroke. However, the optimal timing of AhR antagonist administration for maximum neuroprotective efficacy has yet to be established. The present study explored this issue via MRIs in rats with transient ischemic stroke and demonstrated that infarct volume and apoptosis were alleviated in rats that received AhR antagonists 10 or 50 minutes after ischemia. In addition, the timing of AhR antagonist administration was shown to affect edema formation caused by transient ischemic stroke.

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