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Abstract #1954

Chemogenetic neuromodulation of striato-cortical direct pathway projections cause alterations in brain-wide network connectivity

Marija Markicevic1, Oliver Sturman 2, Johannes Bohacek2, Markus Rudin3,4, Nicole Wenderoth1, and Valerio Zerbi1
1Neural Control of Movement lab, DHEST, ETH Zurich, Zurich, Switzerland, 2Laboratory of Molecular and Behavioural Neuroscience, DHEST, ETH Zurich, Zurich, Switzerland, 3Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 4Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

RsfMRI is used to investigate healthy and diseased brains via temporal correlations of distinct brain regions i.e. functional connectivity (FC). However, this gives little insight into the contribution of specific cell-types to the recorded signals. To tackle this, we measured rsfMRI in mice while chemogenetically exciting or inhibiting D1 expressing cells in dorsomedial striatum (dmCP) via DREADDs. Initial results illustrate opposing effects of excitation and inhibition on FC, observed only within anatomically connected nodes of corticostriatal circuitry. These results are the first, necessary step for further disentangling the role of dmCP on motor control and behavior.

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