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Abstract #1955

In vivo detection of neuroinflammation in rats using Manganese-Enhanced MRI (MEMRI)

Satoshi Fujiwara1, Sosuke Yoshinaga1, Shigeto Iwamoto1, Sayaka Shibata2, Aiko Sekita2, Nobuhiro Nitta2, Tsuneo Saga2, Ichio Aoki2, and Hiroaki Terasawa1
1Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 2Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan

Neuroinflammation is initiated by many types of neural disorders as a defensive response of the innate immune system in the central nervous system (CNS). Neuroinflammation is typically accompanied by the disruption of Ca2+ homeostasis. Manganese chloride (MnCl2) is a useful positive MRI contrast agent that enters activated cells through Ca2+ channels, and is utilized in Manganese-Enhanced MRI (MEMRI) for functional neuroimaging. We sought to determine whether MEMRI could be used to assess the cellular/molecular alterations caused by acute neuroinflammation in vivo, by focusing on Mn2+ accumulation in the rodent brain.

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