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Abstract #1956

Regional Mapping of Glutamate Distributions in a Healthy Rat Brain Using Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI

Do-Wan Lee1, Hwon Heo2, Chul-Woong Woo3, Jae-Im Kwon3, Su Jung Ham4, Yeon Ji Chae2, Kyung Won Kim1,4, Jeong Kon Kim1, Dong-Cheol Woo2,3, and Dong-Hoon Lee5
1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 2Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 3Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, 4Asan Image Research, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, 5Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia

Detecting glutamate signals in vivo within the brain may have a diagnostic potential. Recently, with many translational research efforts leading to clinical trials, presenting the normal in vivo glutamate distribution in pre-clinical data to establish a database for pre-clinical studies can be valuable. In this abstract, we investigated glutamate signal distributions in multiple brain regions of a healthy rat brain using GluCEST imaging. Quantified GluCEST signals showed significant differences between white and gray matter regions. Our findings and investigations yield a valuable database and insights for comparing glutamate signal changes in pre-clinical brain diseases.

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