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Abstract #1960

Improving T2 Sensitivity of Magnetic Resonance Fingerprinting for Simultaneous Quantification of Gadolinium and 17O-Water Concentration

Yuning Gu1, Yong Chen2, Jesse I. Hamilton3, Kihwan Kim1, Ciro Ramos-Estebanez4, Chris A. Flask2, Nicole Seiberlich2,3, Charlie Androjna5, and Xin Yu1,2,6
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 3Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 4Department of Neurology, Case Western Reserve University, Cleveland, OH, United States, 5Cleveland Clinic Pre-Clinical Magnetic Resonance Imaging Center, Cleveland Clinic Foundation, Cleveland, OH, United States, 6Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Simultaneous quantification of intravenously injected Gadolinium (Gd) and 17O-water through T1 and T2 shortening effect enables evaluation of BBB permeability to large and small molecules under pathological conditions. Magnetic resonance fingerprinting allows fast and simultaneous T1 and T2 mapping, though improvement in T2 sensitivity is required for accurate quantification of 17O-water in brain. This study demonstrates that the combination of T2-preparation module and small flip angle improves the accuracy in T2 estimation in mouse brain. Further, the feasibility of using MRF method to quantify Gd and 17O-water concentration was explored in a phantom study.

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