Abstract #1960

Improving T2 Sensitivity of Magnetic Resonance Fingerprinting for Simultaneous Quantification of Gadolinium and 17O-Water Concentration

Yuning Gu¹, Yong Chen², Jesse I. Hamilton³, Kihwan Kim¹, Ciro Ramos-Estebanez⁴, Chris A. Flask², Nicole Seiberlich^2,3, Charlie Androjna⁵, and Xin Yu^1,2,6

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ⁴Department of Neurology, Case Western Reserve University, Cleveland, OH, United States, ⁵Cleveland Clinic Pre-Clinical Magnetic Resonance Imaging Center, Cleveland Clinic Foundation, Cleveland, OH, United States, ⁶Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Simultaneous quantification of intravenously injected Gadolinium (Gd) and ¹⁷O-water through T₁ and T₂ shortening effect enables evaluation of BBB permeability to large and small molecules under pathological conditions. Magnetic resonance fingerprinting allows fast and simultaneous T₁ and T₂ mapping, though improvement in T₂ sensitivity is required for accurate quantification of ¹⁷O-water in brain. This study demonstrates that the combination of T₂-preparation module and small flip angle improves the accuracy in T₂ estimation in mouse brain. Further, the feasibility of using MRF method to quantify Gd and ¹⁷O-water concentration was explored in a phantom study.

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