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Abstract #1961

Disrupted integration of single-subject gray matter networks in suicidality of MDD

Huiru Li1, Jing Yang1, Huawei Zhang1, Li Yin2, Qiyong Gong1,3, and Zhiyun Jia1,4
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, 3Psychoradiology Research Unit of Chinese Academy of Medical Sciences (2018RU011), Chengdu, China, 4Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China, Chengdu, China

In this study, we explore suicidal brain of depression from the level of network connection to capture the complex connectivity alterations of gray matter networks that support higher cognitive and affective processes. We constructed single-subject morphological brain gray matter networks and small-world parameters (Cp, Lp, γ, λ and σ), network efficiency parameters (Eloc and Eglob) and nodal properties (nodal degree, efficiency and centrality). We found decreased σ/Eglob and increased Lp/λ in SU compared to PC and HC. In summary, suicidality involves complex neocortical network organization and showed a weaker integration compared PC and HC.

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