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Abstract #1965

Brain alternations after smoking cessation: An arterial spin labeling study

Guan-Jie Wang1, Chun-Ming Chen2, and Shin-Lei Peng1
1Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan

Although the unfavourable effects of cigarette smoking on the brain have been demonstrated in current smokers, it is unclear whether the neurotoxic effects of smoking on the brain are permanent or reversible after smoking cessation. Our results showed that ex-smokers had a decreased CBF when compared to never-smokers, especially in the posterior cingulate cortex (PCC). The present findings may explain in part the frequently reported cognitive dysfunctions in ex-smokers. However, the affected brain region was less extensive than the previous studies which compared current smokers and never smokers, suggesting the potential to partially recover from smoking-related CBF deficit.

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