Widespread progressive cortical thinning is a long-standing finding in Psychotic Spectrum Disorders (PSD). While previous histological studies have documented an array of microstructural deficits in the thinning cortex in PSD few techniques have been available to examine these microstructural changes in vivo. We employed the diffusion kurtosis imaging (DKI) technique alongside the classical T1-weighted measure of cortical thickness to describe microstructural changes in the PSD cortex over the first 10 years of the illness. We found, for the first time, that DKI metrics of tissue complexity were significantly positively related to PSD illness progression in the cortex.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords