Over 300 million people are suffering from various degrees of depression worldwide. The level of depression severity is a significant risk factor for suicidal behavior. In this study, we used generalized q-sampling imaging (GQI) integrating with clinical diagnostic scale in the suicidal ideation and non-suicidal ideation depressive patients. The multiple regression was performed to identify the association between the GQI indices and the clinical scales. Our results indicated that the demyelination of precuneus may relate to the suicidal ideation in depressive patients.