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Abstract #1968

Structural alterations in functional movement disorders: a diffusion weighted imaging study

Silvina G Horovitz1, Jacob Parker1, Patrick Bedard1, Carine Maurer1,2, and Mark Hallett1
1MNB - HMCS, NINDS - NIH, Bethesda, MD, United States, 2School of Medicine, Stony Brook University, Stony Brook, NY, United States

Functional movement disorders (FMD) patients have an overactive limbic system and an abnormal sense of self-agency. Using diffusion data on a population of 44 (FMD) patients and 44 matched controls, we identified structural anomalies in motor and limbic related areas. ‘Stronger’ (higher FA) limbic white matter reinforces the idea of enhanced limbic effects. Less integrity (higher trace) in areas of the motor system might contribute to the lack of agency.

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