A long disease course of Bipolar I Disorder (BD-I) brings not only with it mood episodes and cognitive impairments, but a progressive change in grey matter morphology. To ascertain how mood episode variables such as type, amount and duration might have an effect on cortical thickness, we conducted a preliminary study in 32 patients from a larger longitudinal study. We found a negative correlation between right parietal lobe thickness and amount of depressive episodes between years 1 and 3 of the disease. These data suggest that early disease course morphological changes may be affected by presence of multiple depressive episodes.
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