Integrated PET/MR platform was used to observe the functional and metabolic effective connectivity (FC, MEC) patterns between 4 default mode network nodes for premature ejaculation patients, at resting-state and after-ejaculation-state. Significant increased FC between medial prefrontal cortex and posterior cingulate cortex (PCC) and decreased metabolic in PCC were found, after ejaculation. MEC pathways were not the same in different state, but the strength differences of MEC were not significant. There was significant positive correlation between intravaginal ejaculation latency time and the resting-state metabolism in PCC, controlling age factor. These findings gave new thoughts of PE diagnosis and treatment.