Abstract #1971

Altered transient connectivity states at rest in Tourette’s syndrome

Shukti Ramkiran^1,2,3, Ravichandran Rajkumar^1,2,3, N. Jon Shah^1,3,4,5, and Irene Neuner^1,2,3

¹Institute of Neuroscience and Medicine - 4 (INM-4), Forschungszentrum Juelich, Juelich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, Juelich, Germany, ⁴Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁵Institute of Neuroscience and Medicine - 11 (INM-11), JARA, Forschungszentrum Juelich, Juelich, Germany

Analysis of dynamic functional connectivity enables identification of spatio-temporal variations in functional connectivity. This is useful in identifying transient states of abnormalities in various brain disorders. Tourette syndrome (TS) is a neurodevelopmental disorder characterized by multiple motor and at least one vocal or phonic tic. We identified eight distinct states in TS patients and healthy controls (HC) using spectral clustering. Our results show preferential state dominance and increased inter-state variability in TS patients as compared to healthy controls.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.