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Abstract #1973

The association between stimulant medication, pharmacological MRI, and ADHD symptom severity in the mature and developing brain.

Antonia Kaiser1, Anouk Schrantee1, Ramon Lindauer2, Marco Bottelier3, Paul J. Lucassen4, and Liesbeth Reneman1
1Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Child and Adolescent Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Child- and Adolescent Psychiatry, GGZ Noord-Holland Noord, Triversum, Alkmaar, Netherlands, 4Brain Plasticity group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands

We previously used pharmacological MRI (phMRI) to demonstrate that four months of methylphenidate treatment alters dopamine function after washout in medication-naïve children, but not adults, with ADHD. Here, we show in the same children at a 4-5 year follow-up, that the baseline phMRI response in the thalamus and anterior cingulate cortex predicts ADHD severity (hyperactivity scale). However, this association was not moderated by cumulative medication dose. Moreover, no association between phMRI response and symptom severity was found in adults.

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