Abstract #1973

The association between stimulant medication, pharmacological MRI, and ADHD symptom severity in the mature and developing brain.

Antonia Kaiser¹, Anouk Schrantee¹, Ramon Lindauer², Marco Bottelier³, Paul J. Lucassen⁴, and Liesbeth Reneman¹

¹Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Child and Adolescent Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Child- and Adolescent Psychiatry, GGZ Noord-Holland Noord, Triversum, Alkmaar, Netherlands, ⁴Brain Plasticity group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands

We previously used pharmacological MRI (phMRI) to demonstrate that four months of methylphenidate treatment alters dopamine function after washout in medication-naïve children, but not adults, with ADHD. Here, we show in the same children at a 4-5 year follow-up, that the baseline phMRI response in the thalamus and anterior cingulate cortex predicts ADHD severity (hyperactivity scale). However, this association was not moderated by cumulative medication dose. Moreover, no association between phMRI response and symptom severity was found in adults.

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