Abstract #1974

Hyperconnectivity among larger-scale intrinsic functional networks in drug-naïve children with attention-deficit/hyperactivity disorder

Yingxue Gao¹, Xuan Bu¹, Kaili Liang¹, Hailong Li¹, Lianqing Zhang¹, Lu Lu¹, Shi Tang¹, Yanlin Wang¹, Xinyu Hu¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China

We used seed-based analysis and independent component analysis to investigate functional connectivity among five resting-sate networks including the default mode network (DMN), central executive network (CEN), salience network (SN) sensorimotor network (SMN) and affective network (AN) in children with attention-deficit/hyperactivity disorder (ADHD). Hyperconnectivity was found both within and between these networks. Our findings highlight the “hub” role of the DMN and the CEN among all these functional networks in the mechanism of network dysfunction in ADHD children.

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