Mapping structural trajectories across adolescence provides valuable insights into the “typical” pathway as well as the developmental emergence of mental illness during this dynamic period. Here we present preliminary findings investigating the relationship between the subcortical structures, hippocampus and amygdala (sub-structures known to play important roles in fear pathways and higher order executive functions) and psychological distress measures from the first two time-points in the Longitudinal Adolescent Brain Study. By determining the neuronal changes that present with the psychological symptoms of mental illness, potential efficacious, targeted interventions become a possibility.
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