Abstract #1979

Relative modulations of left DLPFC connectivity with four patho-physologically relevant targets after repetitive TMS in major depression

Pallab K Bhattacharyya^1,2, Murat Altinay³, Xuemei Huang¹, Mark Lowe¹, and Amit Anand³

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ²Radiology, Cleveland Clinic Lerner College of Medicine, CLEVELAND, OH, United States, ³Neurogolical Institute, Cleveland Clinic, Cleveland, OH, United States

Abnormalities of resting state functional connectivity of several networks have been implicated in the pathology of major depressive disorder. Modulations of functional connectivity of left dorsolateral prefrontal cortex (DLPFC), the site of repetitive transcranial magnetic stimulation (rTMS) for patients inadequately responsive to medication, with four patho-physiologically relevant nodes were studied following rTMS therapy. While the group (N=6) showed improvement in depression following the therapy, only connectivity of left DLPFC with bilateral inferior parietal lobule changed its course – no such change was apparent in connectivity with bilateral anterior cingulate, anterior insula and middle temporal gyrus.

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